NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
نویسندگان
چکیده
منابع مشابه
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we show that nico...
متن کاملNicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
OBJECTIVE Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear efficacious in elevating muscle NAD+. Here we sought to identify the pathways skeletal muscle cells utilize to synthesize NAD+ from NMN and NR ...
متن کاملIdentification of Isn1 and Sdt1 as Glucose- and Vitamin-regulated Nicotinamide Mononucleotide and Nicotinic Acid Mononucleotide 5 -Nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside*
Katrina L. Bogan, Charles Evans , Peter Belenky, Peng Song, Charles F. Burant , Robert Kennedy, and Charles Brenner From the Biochemistry Graduate Program, Dartmouth Medical School, Lebanon, New Hampshire 03756, the Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, and the Department of Chemistry and the Michigan Metabolomics and Obesity Center, ...
متن کاملNicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+
Although NAD(+) biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD(+) precursors have been reported to accelerate aging but not to extend lifespan. In eukaryotes, nicotinamide riboside is a newly discovered NAD(+) precursor that is converted to nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2. In this study, we d...
متن کاملNicotinamide mononucleotide pyrophosphorylase activity in animal tissues.
An enzyme which catalyzes the formation of nicotinamide mononucleotide in the presence of nicotinamide, S-phosphoribosylpyrophosphate, adenosine triphosphate, and Mgff has been purified from rat liver. The reaction is highly specific for ATP and is not substituted for by a variety of nucleotides. Enzymic activity has been found in all of the tissues studied, and in the crude homogenate it is ap...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms13103